We supply good quality Simvastatin CAS 79902-63-9
Place of Origin: Anhui,China (Mainland)
Type:Antipyretic Analgesics and NSAIDs, Auxiliaries and Other
Medicinal Chemicals, Blood System Agent
Grade Standard:Medicine Grade
Appearance :White crystalline powder
Melting point:139 °C
Simvastatin is a statin hypolipidemic drugs used to control blood
cholesterol levels and prevent cardiovascular disease. Simvastatin is a fermentation product of
Aspergillus terreus synthetic derivatives.
The primary uses of simvastatin are to treat dyslipidemia and to
prevent atherosclerosis-related complications such as stroke and
heart attacks in those who are at high risk. It is recommended to
be used as an addition to a low-cholesterol diet.
In the Scandinavian Simvastatin Survival Study (a
placebo-controlled, randomized clinical trial of five years'
duration), simvastatin reduced overall mortality in people with
existing cardiovascular disease and high LDL cholesterol by 30% and
reduced cardiovascular mortality by 42%. The risks of heart attack,
stroke, or needing a coronary revascularization procedure were
reduced by 37%, 28%, and 37%, respectively.
The Heart Protection Study evaluated the effects of simvastatin in
people with risk factors including existing cardiovascular disease,
diabetes, or stroke, but having relatively low LDL cholesterol. In
this trial, which lasted 5.4 years, overall mortality was reduced
by 13% and cardiovascular mortality was reduced by 18%. People
receiving simvastatin experienced 38% fewer nonfatal heart attacks
and 25% fewer strokes.
Simvastatin has been used to explore whether statins have an effect
on delaying on the onset and progression of age-related macular
degeneration (AMD). Results from one trial showed participants
assigned to simvastatin had lower odds (0.51 OR) of having AMD
progression at three years compared to those assigned to placebo,
though the results were not significant. Overall, evidence is
insufficient to conclude that simvastatin has an effect in delaying
the onset and progression of AMD.
1kg with double plastic container inside/Aluminum foil bag ;
20kg with double plastic container inside/Fiber drum outside.Or as
1. Stored in a cool and dry well-closed container and in ventilated
2. kept away from moisture and strong light or high temperature.
3. Two years under well storage situation and stored away from
direct sun light.
|Characters||White to off-white powder||A white powder|
|Specific optical rotation||+285--+298°||+290°|
|Practically insoluble in water; freely soluble in chloroform, in
methanol, and in alcohol; Sparingly soluble in propylene glycol;
very slightly soluble in hexane|
|Loss On drying||≤0.5 %||0.04%|
|Residue on Ignition||≤0.1%||0.04%|
|Lovastatin and epilovastatin||≤1.0%||0.38%|
|Any other individual impurity||≤0.10%||0.03%|
|Total impurities (except lovastatin and epilovastatin)||≤1.0%||0.52%|
Residual organic solvents
|Assay (on dry basis)||98.0—102.0%||99.3%|
|Conclusion||It complies with all the requirements of USP34|