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Simvastatin CAS 79902-63-9 Blood System Agents Hypolipidemic agents API GMP

Categories Pharmaceutical Raw Materials
Brand Name: Health Herb
Model Number: USP EP
Certification: GMP
Place of Origin: CHINA
Price: Negotiable
Supply Ability: 10MT/MONTH
Delivery Time: 7 DAYS
Packaging Details: 20KGS/DRUM
Name: Simvastatin
CAS: 79902-63-9
MF: C25H38O5
MW: 418.57
Usage: Hypolipidemic agents
Appearance: White crystal
Standard: USP
EINECS No.: 404-520-2
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    Simvastatin CAS 79902-63-9 Blood System Agents Hypolipidemic agents API GMP

    We supply good quality Simvastatin CAS 79902-63-9


    CAS No.:79902-63-9

    Other Names:Simvastatin


    EINECS No.:404-520-2

    Place of Origin: Anhui,China (Mainland)

    Type:Antipyretic Analgesics and NSAIDs, Auxiliaries and Other Medicinal Chemicals, Blood System Agent

    Grade Standard:Medicine Grade

    Brand Name:JOYE


    Appearance :White crystalline powder

    Product name:Simvastatin

    Molecular Weight:418.57


    Melting point:139 °C


    Simvastatin is a statin hypolipidemic drugs used to control blood cholesterol levels and prevent cardiovascular disease. Simvastatin is a fermentation product of Aspergillus terreus synthetic derivatives.

    The primary uses of simvastatin are to treat dyslipidemia and to prevent atherosclerosis-related complications such as stroke and heart attacks in those who are at high risk. It is recommended to be used as an addition to a low-cholesterol diet.

    In the Scandinavian Simvastatin Survival Study (a placebo-controlled, randomized clinical trial of five years' duration), simvastatin reduced overall mortality in people with existing cardiovascular disease and high LDL cholesterol by 30% and reduced cardiovascular mortality by 42%. The risks of heart attack, stroke, or needing a coronary revascularization procedure were reduced by 37%, 28%, and 37%, respectively.

    The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke, but having relatively low LDL cholesterol. In this trial, which lasted 5.4 years, overall mortality was reduced by 13% and cardiovascular mortality was reduced by 18%. People receiving simvastatin experienced 38% fewer nonfatal heart attacks and 25% fewer strokes.

    Simvastatin has been used to explore whether statins have an effect on delaying on the onset and progression of age-related macular degeneration (AMD). Results from one trial showed participants assigned to simvastatin had lower odds (0.51 OR) of having AMD progression at three years compared to those assigned to placebo, though the results were not significant. Overall, evidence is insufficient to conclude that simvastatin has an effect in delaying the onset and progression of AMD.


    1kg with double plastic container inside/Aluminum foil bag ;
    20kg with double plastic container inside/Fiber drum outside.Or as your request.

    1. Stored in a cool and dry well-closed container and in ventilated area.
    2. kept away from moisture and strong light or high temperature.
    3. Two years under well storage situation and stored away from direct sun light.


    CharactersWhite to off-white powderA white powder
    1. IR
    1. HPLC
    Specific optical rotation+285--+298°+290°


    Practically insoluble in water; freely soluble in chloroform, in methanol, and in alcohol; Sparingly soluble in propylene glycol; very slightly soluble in hexane


    Loss On drying≤0.5 %0.04%
    Residue on Ignition≤0.1%0.04%
    Heavy Metals≤20ppm<20ppm
    Chromatographic purity
    Simvastatin hydroxyacid≤0.4%0.09
    Lovastatin and epilovastatin≤1.0%0.38%
    Methylene simvastation≤0.4%0.09%
    Acetyl simvastatin≤0.4%0.05%
    Anhydro simvastatin≤0.4%0.10%
    Simvastatin dimer≤0.4%0.11%
    Any other individual impurity≤0.10%0.03%
    Total impurities (except lovastatin and epilovastatin)≤1.0%0.52%

    Residual organic solvents



    Methylene chloride







    Assay (on dry basis)98.0—102.0%99.3%
    ConclusionIt complies with all the requirements of USP34

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