Indapamide Raw Steroid Powder 26807-65-8 Cardiac Failure
Pharmaceutical Raw Materials
1. Basic Info
1). Diuretic antihypertensive drug White needle crystal or
crystalline powder, odorless, tasteless. It is almost insoluble in
water or dilute hydrochloric acid, while it can be dissolved in
ethanol or ethyl acetate, and it is soluble in acetone, acetic
acid, slightly soluble in chloroform or ether.
2). Indapamide is currently the most popular non-prescription
diuretic antihypertensive drug with good efficacy, stable blood
pressure, fewer side effects, etc. It was originally developed for
the first time by the French Servier (Servier) pharmaceutical
company. Indapamide film-coated tablets were first successfully
developed by Tianjin Lisheng pharmaceutical company in 1988 in
China. The trade name is "life than the mountains."
3). In the mid-1990s, Zhejiang Apeloa pharmaceutical, Yantai Xiyuan
pharmaceutical factory, Zhejiang East medicine, Dongguan million
into pharmaceuticals, Shanxi Asia-medicine, medicine Fuxin Shibata,
Puyang the yuan Pharmaceutical, Chongqing Friends of pharmaceutical
drugs, 8 pharmaceutical formulations were approved for production.
In the late 1990s, the French pharmaceutical company Servier took
indapamide sustained-release tablets into China. The trade name is
"Na Ionizers." Subsequently, indapamide raw material drug
localization has been progress. Currently, seven companies have
been allowed to produce raw material drug types.
4). Indapamide have diuretic and calcium antagonist dual effect by
inhibiting the proximal end of the distal convoluted tubule Na+
reabsorption, resulting in diuresis, while by blocking Ca2+ influx
especially a higher selectivity for vascular smooth muscle to
dilate the small blood vessels of the outer periphery, resulting in
antihypertensive effect. But the effect to vascular smooth muscle
is stronger than the diuretic effect.
5). It can lower blood pressure with lower dose compared to
diuretic effect. Higher dose will display diuretic effect. But
there is no disadvantage compared to thiazide diuretics, that it
does not cause orthostatic hypotension, flushing and reflex
tachycardia, nor blood lipids, glucose metabolism and renal
function. The therapeutic dosage for heart rate, cardiac output,
electrocardiogram are no significant change, as well as for the
central nervous system and autonomic.
6). There is antihypertensive effect by oral for 2~3h, maintaining
24h. single medication has good effect. Diuretic effect appears at
3h, achieving maximum effect for 4~6h. It is different from other
diuretics. This product is fat-soluble. After oral administration,
there is highest concentration in the liver, renal plasma, and
lower concentration in heart, lung, muscle, fat.
7). This product excretes from the kidney mainly by metabolites and
5% of the prototype. Indapamide is for mild to moderate
hypertension, and for sodium retention caused by congestive heart
failure. It is also applied to hypertension with renal failure,
diabetes mellitus, high blood lipids. Single medication has
significant effect. It is combined with β-receptor blockers that
has better effect. Because the drug has a diuretic effect, it can
cause hypokalemia, which can add potassium.
|WHITE TO OFF-WHITE, CRYSTALLINE POWDER.SOLUBLE IN METHANOL,|
IN ALCOHOL,IN ACETONITRILE,IN GLACIAL ACETIC ACID,AND IN ETHYL
ACETATE;VERY SLIGHTLY SOLUBLE IN ETHER AND IN CHLOROFORM;
PRACTICALLY INSOLUBLE IN WATER.
|3. LOSS ON DRYING||≤3.0%||2.0%|
|4. OVIS||MEETS THE REQUIREMENTS||CONFORMS|
|5. RESIDUE ON IGNITION||≤0.1%||CONFORMS|
|6. CHROMATOGRAPHIC PURITY(TLC)||SINGLE IMPURITY≤0.5%||CONFORMS|
(ON THE DRIED BASIS)
|CONCLUSION:ALL THE ITEMS CONFORM TO THE SPECIFICATION OF USP33.|