Ambiphilic Bile Acid TUDCA Api Intermediates Tauroursodeoxycholic
Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is
the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans
are found to have trace amounts of TUDCA. However, bears contain
large amounts of TUDCA in their bile; UDCA and conjugates comprise
about 47% of the bile in American black bears and up to 76% in
TUDCA has been used in ancient Asian pharmacopoeias for its
supposed beneficial effects. UDCA is produced in several countries
for the treatment of gallstones and liver cirrhosis. It is not
approved by the Food and Drug Administration, in the U.S. while
UDCA is approved in the United States for the treatment of primary
biliary cirrhosis Ongoing research is finding TUDCA has diminishing
apoptotic effects, helping with cardiac function, Huntington's
disease, Parkinson's Disease, and stroke.Recently, TUDCA has been
found to have protective effects in the eye, especially concerning
retinal degenerative disorders
Chinese medicine has used animal bile for hundreds of years as a
medicine to treat "heat" illnesses. It was used to relieve spasms,
reduce fever, and improve visual acuity. Bile is naturally
synthesized via cholesterol, consisting of compounds including
taurochenodeoxycholic acid, ursodeoxycholic acid, and
chenodeoxycholic acid. However, UDCA and TUDCA were first
synthetically developed in 1954 in Japan.
A bile related salt for isolation of lipids
- Cooling blood and hemostasis,clearing heat and diuresis,
- As an effective hemostat or blood coagulant that has been used to
reduce or stop hemorrhage and bleeding from internal organs,
particularly controlling profuse menstruation, postpartum and
uterine bleeding, and blood in the urine.
- Treatment of high blood pressure,dysentery etc.
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