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35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine

Categories Active Pharmaceutical Ingredient
Brand Name: VANZ
Model Number: Triciribine
Certification: ISO9001
Place of Origin: China
MOQ: 1G
Price: USD
Payment Terms: T/T, Western Union, MoneyGram
Delivery Time: 3-5 Working days
Packaging Details: Aluminum foil bags or drum
Name: Triciribine
CAS: 35943-35-2
Appearance: white powder
Purity: 99%
Test method: HPLC
Formula: C13H16N6O4
Company Info.
Wuhan Vanz Pharm Inc.
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    35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine

    35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine

    Introduction

    • Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase.
    • Triciribine exhibits maximum growth inhibition around 1-10 μM and inhibits phosphorylation of Akt, as well as downstream p70S6K, to basal levels at 100μM (IC50 = 130 nM).
    • Triciribine shows particular promise for inhibiting growth in Nf1 and Trp53 mutant astrocytoma cells in a grade-dependent manner. The WHO II K1861-10 line is inhibited, incompletely (69% maximum inhibition), with a GI50 value of 1.7 μM for Triciribine, whereas higher-grade tumor lines (KR158, KR130, and SF295) are inhibited to a greater extent (>80% maximum inhibition) at lower GI50 values (0.4–1.1 mM).
    • Importantly, Triciribine is much less effective at inhibiting primary astrocytes (GI5013.6 mM), suggesting that this inhibitor may show specificity for tumor cells. Triciribine inihibits HIV-1with an IC50 of 20 nM. Greater than 90% inhibition is achieved at 0.1μM and complete inhibition of syncytia formation is achieved at 5μM.

    Basic Information


    Chemical nameTriciribine /API-2
    CAS NO.35943-35-2
    SynonymAPI-2;nosyl-;3-amine;hthylene;uranosyl-;NSC 154020;TRICIRIBINE;AKT INHIBITOR V;API-2 (Tricirbine)
    Molecular FormulaC13H16N6O4
    Molecular Weight320.3
    Store atNormal ROOM
    Purity99%
    Appearancewhite powder
    Flash point388.3°C
    Boiling point718.5°C at 760 mmHg
    Density2.02g/cm3


    • Associated cell toxicity in the same cell line for Triciribine is 46 μM, resulting in selectivity indices of 2250. Triciribine markedly inhibits HIV-1-induced p24 core antigen production, reverse transcriptase, and infectious virus production in a dose-dependent manner using HIV-1 acutedly infected CEM-SS, H9, and persistently infected H9III B and U1 cells.Triciribine inhibits Akt phosphorylation at Thr308 and Ser473 and Akt activity in the human prostate cancer cell line PC-3.
    • Triciribine sensitizes PC-3 cells to TRAIL- and anti-CD95-induced apoptosis, whereas the cells remain resistant to DNA damaging chemotherapeutics.Triciribine is highly selective for Akt and does not inhibit the activation of phosphatidylinositol 3_-kinase, phosphoinositide-dependent kinase-1, protein kinase C, serum and glucocorticoid-inducible kinase, protein kinase A, signal transducer and activators of transcription 3, extracellular signal-regulated kinase-1/2, or c-Jun NH2-terminal kinase.

    Shipping item:


    1. CIP by courier to your door(UPS, FedEx, DHL, EMS,TNT,HONGKONG POST).

    2. CIF BY SEA OR AIR in bulk quantity.

    Delivery time: Within 3 days after receive payment.



    Warm welcome to visit my factory indeed.


    Our company is a direct manufacturer of APIs, pharmaceutical intermediates and fine chemicals. We 've developed a series of APIs ranging in various indications such as respiratory system, anti neoplastic, anti diabetes and anti depressant, etc. We also provide custom synthesis service of novel APIs and pharmaceutical intermediates.

    Quality 35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine for sale
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