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Skin Care Medical Products Mt-2 Melanotan II Mt-2 for For Lose Weight Mt-II, Mt-1 CAS 75921-69-6

Categories Testosterone Anabolic Steroid
Brand Name: JNJG
Model Number: 121062-08-6
Certification: USP BP SGS KOSHER
Place of Origin: CHINA
MOQ: Negotiable
Price: negotiation
Payment Terms: TT, Money Gram, Western Union, Bitcoin
Supply Ability: 500kg/per week
Delivery Time: within 12 hours after you payment
Packaging Details: 1kg/ foil bag or as your requirement
CAS: 121062-08-6
Purity: 99%
Free acid: 0.31%
Loss on drying: 0.34%
Testosterone Base: Testosterone Base
product: Dutasteride
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    Skin Care Medical Products Mt-2 Melanotan II Mt-2 for For Lose Weight Mt-II, Mt-1 CAS 75921-69-6
    skype: chenycphar
    whatsapp: +86-13026588418

    Mt-2/ Melanotan II
    CAS 121062-08-6

    MF: C50H69N15O9
    MW: 1024.180
    Density: 1.43 g/cm3
    Refractive Index: 1.669
    Water: 5 mg/mL, soluble in water
    Solubilities: 5 mg/mL, soluble in water
    Appearance: White powder
    Grade: Pharmaceutical Grade
    Storage: Closed, below 20o C preservation
    Lead time: Within 12 hours upon receipt of payment
    Delivery time: 4-6 working days
    Delivery: EMS, DHL, TNT, FedEx, UPS

    Usage: Melanotan 2 has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning. Melanotan 2 has been researched extensively
    for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.

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    Melanotan I ([Nle4-DPhe7]α-melanocyte-stimulating hormone analog) is a synthetic hormone that is stimulating the release of melanocyte-hormone in animal cells. These melanocyte-hormones are the
    ones responsible for the pigmentation of the skin due to their interaction with melanocortin-1 receptors
    in the epidermis. These hormones are being released from the pars intermedia of the pituitary glands in some of the eukaryotic animal species. However, these are also prominent in the keratinocytes and the melanocytes of the human skin (Hadley 1982). The molecular structure is shown below:

    It was attempted to be extracted from biological matrices such as cell culture transport media and human plasma. This was done by relatively fast and isocratically within 8.0 minutes using the C8 reversed column. In order to successfully isolate the said protein, the mobile phase has been optimized using 0.1 molar of phosphate buffer with 18 μl/l triethylamine at pH 2.50 with an average flow rate of 1 iml/min and being detected at 214 nm. This study have shown that results are very consistent and has already been used in investigating the transport of melanotan-I in the caco-2 cell monolayer model (Surendran et al. 1995).

    Studies have shown that in organisms that do not possess fur or thick hair, the superpotent derivative
    of the menocyte stimulating hormone which is the melanotan-1 have induced tanning. Furthermore, it
    has already been demonstrated that malenotan-1 also induces eumelanin synthesis in the skin of
    animals, especially humans which is coincidental with its tanning effect (Dorr et al. 2004). When combined with UV-B light or sunlight, a tanning synergy between these factors was strongly observed. Furthermore, it was shown that when melanotan-1 was combined with sunlight, it produced a long-lasting tan at the
    sun-exposed back sites. However, when induced in greater amounts, melanotan-1 has been shown to induce side-effects. In the same study conducted by Dorr et al. (2004), nausea was observed in the experimental units. Possible explanation for this is the interaction of the melanotan-1 with the melanocortin-3 receptors which in turn are found in the gastrointestinal tissues of animals.

    The Development of Melanotan 1
    The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona. During the course of study aimed at developing a defense against skin cancer, focus was
    placed on developing a method of stimulating natural melanogenesis, or the natural production of
    melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring
    hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising

    results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects
    whilst possessing an extended half-life for functional therapeutic utilization. The researchers,
    headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule "Melanotan" (later Melanotan-1).

    Melanotan-1 Mechanism of Action - How it Works!
    Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase
    A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.

    No.Steroid RawsCAS No.Concentration of cooking
    1Oxymetholone / Anadrol / Anapolon434-07-120 mg/ml 50mg/ml 100 mg/ml
    2Stanozolol / Winstrol10418-03-820mg/ml 100mg/ml 250 mg/ml
    3Oxandrolone / Anavar53-39-420mg/ml 50mg/ml
    4Methandienone / Dianabol72-63-920 mg/ml 50mg/ml
    5Trenbolone acetate/ Finaject10161-34-975mg/ml 100mg/ml 250mg/ml
    6Trenbolone enanthate--60mg/ml 100mg/ml 250mg/ml
    7Methenolone acetate/ Primobolan434-05-920mg/ml 50 mg/ml
    8Metenolone enanthate/ Primobolan Depot303-42-475mg/ml 100 mg/ml 200mg/ml
    9Drostanolone Propionate/ Masteron521-12-075mg/ml100mg/ml 200mg/ml
    10Drostanolone enanthate/Masteron Enanthate--200mg/ml

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