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100% White Raw Steroid Powders Ethisterone CAS 434-03-7 C21H28O2

Categories Raw Steroid Powders
Brand Name: YCGC
Model Number: 434-03-7
Certification: ISO, KOSHER
Place of Origin: Wuhan, Hubei, China
MOQ: Negotiable
Price: Negotiable
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Supply Ability: 1000kg/month
Delivery Time: 12 hours within your payment is received
Packaging Details: As you require
Molecular Formula: C21H28O2
Molecular Weight: 312.49
CAS Registry Number: 434-03-7
Assay: 99%
EINECS: 207-096-5
Appearance: Off-white powder
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    100% White Raw Steroid Powders Ethisterone CAS 434-03-7 C21H28O2

    100% White Raw Steroid Powders Ethisterone CAS 434-03-7 C21H28O2


    Quick Detail

    NameEthisterone
    CAS No.434-03-7
    FormulaC21H28O2
    Molecular Weight312.49
    EINECS207-096-5
    Assay99%
    AppearanceOff-white powder
    Package1kg/foil bag or according to the customers requirements.
    Density1.13 g/cm3
    Melting Point263-269 °C(lit.)
    Boiling Point446.4 °C at 760mmHg
    Flash Point190.2 °C
    StorageKeep it under seal in cool and dark place

    Description
    Ethisterone (INN, USAN, BAN) (brand names Pranone, Progestoral, Lutocylol, Proluton C, many others), also known as 17α-ethinyltestosterone, pregneninolone, or anhydrohydroxyprogesterone, is a steroidal progestin with androgenic activity which is derived from testosterone and was introduced for medical use in 1939. It was the second progestogen to be marketed (intramuscular progesterone was introduced as Proluton in 1934) and was both the first orally active progestogen and the first progestin (or synthetic progestogen) to be introduced. Although ethisterone has largely been superseded by newer drugs and is now little used, it continues to be available in some countries. Moreover, the 19-nortestosterone progestins, such as norethisterone, are derived from ethisterone and are widely used as hormonal contraceptives and for other indications.


    Pharmacology
    Ethisterone is described as a relatively weak progestogen, similarly to its analogue dimethisterone.


    Androgenic activity
    Based on in vitro research, ethisterone and norethisterone are about equipotent in their EC50 values for the androgen receptor (AR), whereas, conversely, norethisterone shows markedly increased potency relative to ethisterone in terms of its EC50 for the progesterone receptor (PR). As such, there is a considerable separation in the ratios of androgenic and progestogenic activity for ethisterone and norethisterone.
    Moreover, at the larger dosages in which it is used to achieve equivalent progestogenic effect, ethisterone has strong androgenic effects relative to norethisterone and other 19-nortestosterone progestins, and this has limited its clinical use.


    Due to its androgenic activity, ethisterone has been associated with the masculinization of female fetuses in women who have taken it during pregnancy.


    Estrogenic activity
    High dosages of norethisterone and noretynodrel, which are 19-nortestosterone derivatives of ethisterone, were found to be associated with high rates of estrogenic side effects such as breast enlargement in women and gynecomastia in men, as well as with improvement of menopausal symptoms in postmenopausal women. In contrast, ethisterone and other progestogens such as progesterone and hydroxyprogesterone caproate were not associated with such effects, suggesting that they are either not estrogenic or are only weak so. As such, ethisterone does not appear to share the estrogenic activity of norethisterone and noretynodrel.


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    Steroid Raw Powder

      

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