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EE2 Steroid Raw Powder Ethynyl Estradiol CAS 57-63-6 Ethynylestradiol

Categories Raw Steroid Powders
Brand Name: Chembj-Steroid
Model Number: 57-63-6
Certification: HSE, ISO 9001, USP, BP
Place of Origin: China
MOQ: 10g
Price: $10/g
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Supply Ability: 1000kg/month
Delivery Time: 12 hours within your payment is received
Packaging Details: As you require
Molecular Formula: C20H24O2
Molecular Weight: 296.44
CAS Registry Number: 57-63-6
Density: 1.21 g/cm3
EINECS: 200-342-2
Melting Point: 182-183 ° C(lit. )
Appearance: Light-Yellow Crystalline Powder
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    EE2 Steroid Raw Powder Ethynyl Estradiol CAS 57-63-6 Ethynylestradiol

    EE2 Steroid Raw Powder Ethynyl Estradiol CAS 57-63-6 Ethynylestradiol


    Quick Detail


    SynonymsAmenoron; Esteed; Estoral; Estorals; Ethinoral; Ethynylestradiol; Ethynyloestradiol; Eticyclin; Eticyclol
    CAS No.57-63-6
    FormulaC20H24O2
    Molecular Weight296.44
    EINECS200-342-2
    Density1.21 g/cm3
    Melting Point182-183 ° C(lit. )
    Boiling Point457.2 ° C at 760 mmHg
    Flash Point211.2 ° C
    SolubilityEthanol: 50 mg/mL, clear, slightly yellow
    AppearanceOff-White to Light-Yellow Crystalline Powder
    StorageRoom temperature

    Description


    Ethinyl estradiol (EE2) (USP) (former brand name Estinyl), or ethinylestradiol (INN, USAN, JAN), also spelled as ethinylœstradiol (BAN) and also known as 17α-ethynylestra-1,3,5(10)-triene-3,17β-diol, is a synthetic, steroidal estrogen.[8][9][10] It is a derivative of estradiol, the major endogenous estrogen in humans; specifically, EE2 is 17α-ethynylestradiol.[8] EE2 is an orally active estrogen used in almost all formulations of combined oral contraceptives (COCs), being nearly the exclusive estrogen used for this purpose.


    Medical uses


    As Estinyl, EE2 was formerly used for hormone replacement therapy in menopause and the treatment of female hypogonadism, loss of menstruation, dysmenorrhea, acne, prostate cancer, and breast cancer.

    However, in more recent times, EE2 is mainly used in COCs. In contraception, due to concerns of unopposed estrogen action and the possible increased risk of endometrial cancer that accompanies this, EE2 is formulated in combination with progestins. EE2 is little used in menopausal hormone replacement therapy.


    Due to risk of cholestatic hepatotoxicity, it is widely considered that COCs containing EE2 should be avoided in women with a history of cholestasis of pregnancy, hepatic tumors, active hepatitis, and familial defects in biliary excretion.


    Application;


    Inducers of certain cytochrome P450 enzymes such as CYP3A4 can decrease circulating concentrations of EE2. Examples include anticonvulsants like phenytoin, primidone, ethosuximide, phenobarbital, and carbamazepine, azole antifungals like fluconazole, and rifamycin antibiotics like rifampin and rifampicin. Conversely, inhibitors of CYP3A4 and certain other cytochrome P450 enzymes may increase circulating levels of EE2. An example is troleandomycin, which is a potent and highly selective inhibitor of CYP3A4.


    Paracetamol has been found to competitively inhibit the sulfation of EE2, with pretreatment of 1 g paracetamol significantly increasing the AUC levels of EE2 (by 22%) and decreasing the AUC levels of EE2 sulfate in women. The same has been found for ascorbic acid (vitamin C) and EE2, although the significance of the interaction has been regarded as dubious.


    Unlike the case of estradiol, there is probably no pharmacokinetic interaction between smoking (which potently induces certain cytochrome P450 enzymes and markedly increases the 2-hydroxylation of estradiol) and EE2. This suggests that estradiol and EE2 are metabolized by different cytochrome P450 enzymes. There is however still an increased risk of cardiovascular complications with smoking and EE2, similarly to the case of smoking and other estrogens.


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