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rAAT Alpha One Antitrypsin Human Recombinant Protein Protecting Cell Digestion

Categories Recombinant Alpha 1 Antitrypsin
Brand Name: Oryzogen
Model Number: HY303M1
Certification: ISO9001 certificate
Place of Origin: China
MOQ: Negotiation
Price: Negotiation
Payment Terms: T/T
Supply Ability: 1kg per year
Delivery Time: 3-5 days
Packaging Details: 1mg/vial
Source: Rice Grain
Molecular Weigh: 43.1kD
Formulation: rAAT is lyophilized with HSA as the stabilizer
Purity: Greater than 95%
Endotoxin: Less than 1EU/ug
Production Type: Recombinant protein
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    rAAT Alpha One Antitrypsin Human Recombinant Protein Protecting Cell Digestion

    rAAT Alpha One Antitrypsin Human Recombinant Protein Protecting Cell Digestion ​


    Description

    Trypsin can selectively hydrolyze the protein chain composed of the carboxyl group of lysine or arginine, which can digest and denature the protein. The Alpha-1 anti-trypsin, also known as protease inhibitors, can effectively inhibit the trypsin activity, prevents the sticky protein from being decomposed by trypsin during cell growth and thus prevent digestion.


    Quick detail

    1. CAS No.: 9041-92-3
    2. Other Names: rAAT
    3. Place of Origin: Hubei, China (Mainland)
    4. Brand Name: Oryzogen
    5. Model Number: HY303M1
    6. Purity: Greater than 95 % as determined by SDS-PAGE
    7. Source: Rice Grain (Oryza Sativa)
    8. Storage and Handling: Stored at temperatures -20℃ for 12 months
    ItemStandard
    Molecular Weight43.2kD
    stabilizerHSA
    PurityGreater than 95%
    EndotoxinLess than 1EU/ug
    Storage and Handling-20℃ for 12 months
    biological activity3~5mg rAAT ihibit 1 mg PPE(pancreatic porcine elastase) with 10.8 Units/mg.


    Advantages

    1. The chairman of Healthgen Professor Daichang.Yang is one of China's chief scientists. Professor Yang has rechieved the “Thousand Talents program” of the National Central Organization Department, "Hundred Talents Program" of the Organization Department of Hubei Province and Top 10 "Venture Eagle" entrepreneurs.


    2. With years of effort, Healthgen has developed the State-of-the-Art platform called OryzHiExp, having high capacity to express no animal origin proteins and peptides in the rice endosperm cells.


    3. Healthgen recombinant Alpha-1 Antitrypsin (rAAT) has excellent batch consistency. Using self-pollination rice as the bioreactor to express the rAAT with the world's advanced facility and top production proceeding to extract and purify the rAAT, Healthgen can ensure the excellent consistency of rAAT from different batches.


    4. The rice endosperm specific expression platform is easy to be large-scale. The rice endosperm has the protein body, which can keeps proteins stability and bioactivity. At present, the production capacity is almost 1 kg / year.


    Supplemental Description

    Recombinant Alpha 1 Antitrypsin (AAT) is a serine protease inhibitor. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. If it is deficiency, neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children. OsrAAT is derived from rice grain, which contains 384 amino acids with a molecular weight of 43.1kD.

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